Naltrexone: Generic Availability

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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in grown-ups with a body mass index (BMI) greater than 27, provided that they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to smoking cessation treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes showed that patients had a typical weight loss of four.1% instead of participants who have been given placebos) after a 12- month period, while an outside study involving patients with diabetes had the average weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight naturally can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you ought to err to the side of caution and allow FDA do its job and demand some investigation be done so that the public recognizes the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on the medications.

Researchers discovered that participants using this drug for any year, dropped excess weight within 4 weeks and have kept the body weight off during the entire 56 weeks from the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, which may make them more efficient and safer.

Combo-pilling may be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug may also raise blood pressure levels and heart rate, and must not be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure levels, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

Acamprosate also functions eliminate the want to drink through the elimination of the the cravings for having a drink. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate is not yet for sale in the United States. While it has become widely studied in Europe the complete chemical reason that it works remains unknown. It is belief that it interferes with receptors inside brain which process glutamate, which in place alters the way in which ones body reacts to alcohol intake. Several of the European research has revealed a lot of promise with Acamprosate because some of the patients had a nearly double effectiveness for staying sober.